Oftentimes when we think of focused ultrasound, we imagine using it to heat and kill tissue. Unlike thermal ablation, histotripsy uses focused ultrasound to mechanically disrupt the target tissue without heating. Histotripsy turns the tissue into liquid-appearing acellular debris – which is absorbed by the body over one to two months – resulting in effective tissue removal.
Histotripsy has been shown to stimulate a powerful immune response in cancer treatment studies. In the treatment of neurological diseases, transcranial histotripsy can produce well-confined focal treatment in a wide range of locations and volumes in the brain, offering the potential to increase the treatment envelope while decreasing treatment time.
Zhen Xu, PhD, will discuss the basic mechanism, instrumentation, bioeffects, and applications of histotripsy. She will also cover the latest preclinical and clinical trial results of developing histotripsy for the treatment of cancer and neurological diseases.